Archival ReportFolding of the Prefrontal Cortex in Schizophrenia: Regional Differences in Gyrification
Section snippets
Participants
A sample of 57 patients satisfying DSM-IV criteria (17) for schizophrenia and 42 healthy control subjects was recruited. Regional ethics committees (Nottinghamshire and Derbyshire) approved the study, and all participants provided written informed consent. Patients were initially referred by clinicians attached to community mental health teams and rehabilitation services. The diagnosis of schizophrenia was made in a clinical consensus meeting among a team of research psychiatrists (PFL, PM, or
Results
There were no significant differences in demographic features such as age [t(1,96) = −1.32, p = .17] or parental socioeconomic status (Mann–Whitney U test, Z = −1.94, p > .05) between the two groups. The mean total symptom score on the Signs and Symptoms of Psychotic Illness was 10.28 of a maximum of 80 (range: 0–29), indicating a low symptom burden and consistent with recruitment in a stable phase of illness. The mean score on Reality Distortion (Delusions and Hallucinations) among the patient
Discussion
With vertex-wise computation of gyrification index within major sulcogyral regions of prefrontal cortex on three-dimensional brain reconstructions, we have shown significantly altered cortical folding pattern in schizophrenia. Our results confirm our main hypothesis that there are both hypergyric and hypogyric regions in prefrontal cortex of patients with schizophrenia when compared with healthy control subjects. Significant age-related reduction in gyrification index is observed in those
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Surface-based brain morphometry in schizophrenia vs. cannabis-induced psychosis: A controlled comparison
2022, Journal of Psychiatric ResearchAnalysis of local gyrification index using a novel shape-adaptive kernel and the standard FreeSurfer spherical kernel – evidence from chronic schizophrenia outpatients
2020, HeliyonCitation Excerpt :Importantly, some authors suggest that alterations in cortical folding measured with LGI may be regarded as a biomarker of schizophrenia (Matsuda and Ohi, 2018; White and Hilgetag, 2011). However, consistent conclusions are precluded by the discrepancies between the LGI results in the literature, indicating that abnormalities are more related to increased (hypergyria) or decreased (hypogyria) LGI (Nenadic et al., 2015; Palaniyappan et al., 2011; Sasabayashi et al., 2016, 2019). Previous studies on LGI in schizophrenia have mostly reported global suppression of cortical folding in comparison to healthy controls (White and Hilgetag, 2011).
Morphometry and gyrification in bipolar disorder and schizophrenia: A comparative MRI study
2020, NeuroImage: ClinicalCitation Excerpt :Differences regarding brain gyrification findings could reflect regional variation in the abnormalities of gyrification, with age, disease progression and neurodevelopmental factors, all influencing gyrification findings (Bo Cao et al., 2017; Palaniyappan et al., 2011). Of interest to our findings of asymmetric regional gyrification is a previous morphological study in SCZ (Palaniyappan et al., 2011) showing that patients had significant hypo-gyrification in most prefrontal regions. However the most striking finding was that the normal left>right pattern of prefrontal gyrification was reversed in SCZ patients.