Priority CommunicationPotentiated Amygdala Response to Repeated Emotional Pictures in Borderline Personality Disorder
Section snippets
Participants
Thirty-three patients with BPD, 28 patients with SPD, and 32 HCs were included (Table 1; Table S1 in Supplement 1 for additional demographic/clinical/exclusionary criteria details). The groups did not significantly differ in age, gender, or education and all patients met DSM-IV criteria. All patients were unmedicated at the time of their fMRI scan (>6 weeks) and most were never previously medicated. Patients with a history of schizophrenia, psychotic disorder, bipolar (type I) affective
Functional and Structural MRI Acquisition
The MRI scan procedure was conducted on an Allegra head-dedicated 3T scanner (Siemens, Erlangen, Germany) and included a T2, echo planar image, and T1-weighted structural magnetization prepared rapid acquisition gradient-echo (MP-RAGE) scan. See Figure S1 in Supplement 1 for scan parameter details.
Amygdala Activation During Picture Processing
Following picture onset, the BPD patients exhibited an overall amygdala BOLD response curve (averaged across all repeated measures except time) with a much slower return to baseline compared with the HC and SPD groups (Figure 1, top). The HCs showed the smallest amygdala BOLD response peak, while the SPD group showed the greatest and the BPD patients were intermediate. The HCs also had the fastest peak latency; SPD patients showed the slowest; and BPD patients were intermediate, group × time
Discussion
Our study has two novel findings reflecting BPD-related abnormalities in amygdala function. First, BPD patients showed reduced overall habituation (time series) in terms of their BOLD response curve returning to baseline following picture onset. That is, averaged across the three picture conditions (unpleasant, neutral, and pleasant), BPD patients showed a prolonged amygdala response compared with the HC and SPD groups. The region of interest time series showed and the whole-brain analysis
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2022, Progress in Neuro-Psychopharmacology and Biological PsychiatryHyperreactivity and Impaired Habituation of Startle Amplitude During Unpleasant Pictures in Borderline but Not Schizotypal Personality Disorder: Quantifying Emotion Dysregulation
2022, Biological PsychiatryCitation Excerpt :The ability to identify factors underlying this study’s results may guide the development of treatment methods to assist patients with BPD in regulating their emotional responses through improved processing of repeating negatively valenced information, e.g., amygdala neurofeedback (43). Finding impaired AMS habituation to unpleasant pictures in the BPD group is consistent with fMRI work examining amygdala activation during processing of emotional pictures (12) and faces (44). In an anecdotal case report, we reported that, compared with an age- and gender-matched HC subject, a patient with BPD exhibited a deficit in AMS habituation to unpleasant pictures, and in a separate session, event-related fMRI showed a similar blood oxygen level–dependent response to the initial unpleasant pictures but an increased response over time (45).
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