Archival ReportBrain Structural Signature of Familial Predisposition for Bipolar Disorder: Replicable Evidence For Involvement of the Right Inferior Frontal Gyrus
Section snippets
Methods and Materials
We report on two related studies. Study 1 was a two-center genetic HR design study aimed at identifying biological risk factors for BD. We recruited offspring from families of well-characterized adult probands with BD and divided them on the basis of the presence or absence of personal history of mood disorders. Including both affected and unaffected offspring is necessary to establish the presence of neurobiological changes in families and their association with the illness. We performed VBM
Description of the Participants
For Study 1, we recruited 50 Unaffected HR (30 in Halifax, 20 in Prague), 36 Affected Familial (21 in Halifax, 15 in Prague), 19 Young BD (all in Prague), and 49 Control (31 in Halifax, 18 in Prague) participants. At each center, the groups were comparable in age, sex, handedness, and global brain volumes, with the exception of the Young BD participants, who were older than the respective Controls (Table 1, Table 2).
For Study 2, we recruited 17 Li, 12 Non-Li, and 11 Control individuals. The
Discussion
We present replicated evidence for dynamic structural changes of rIFG in the course of BD. The larger rIFG met criteria for biological risk factor of BD, because it was present among both the Unaffected HR and Affected Familial subjects from both centers and was associated with the early stages of illness in an unrelated clinical sample of Young BD participants. Interestingly, the same region was negatively correlated with the duration of illness. As a result, patients with BD who had a
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