Archival ReportTesting the Hypothesis of Accelerated Cerebral White Matter Aging in Schizophrenia and Major Depression
Section snippets
Methods and Materials
Testing of the study’s hypotheses was performed in two distinct cohorts, each with its own normal control group.
Diagnosis and Diagnosis-by-Age Effects for Whole-Brain FA Values
SCZ Cohort. Beta coefficients and their significance for age and gender effects for the whole-brain average FA values are shown in Table 3. The quadratic and linear age models were significant for the whole-brain FA values (p = 6.9×10−5 and 9.2×10−5, respectively). There were no significant main effects on diagnosis. Instead, quadratic effects of the diagnosis-by-age interaction were significant (β2age⁎SCZ =−6.9±3.4·10−6; p = .04) and linear effects of the diagnosis-by-age interaction
Discussion
We aimed to test whether the rates of age-related decline in the integrity of cerebral WM were higher in patients affected with SCZ or MDD than in normal control subjects. In SCZ patients, age-related decline in the whole-brain FA values were more than twice that of control subjects, which was significant under the quadratic model. In contrast, the effects of accelerated aging in the whole-brain FA values were not statistically significant in the MDD patients. Exploration of regional
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