Archival ReportBrain Effects of Cognitive Remediation Therapy in Schizophrenia: A Structural and Functional Neuroimaging Study
Section snippets
Methods and Materials
A controlled, randomized study was carried out with three groups: patients receiving cognitive treatment, patients receiving a different psychological intervention as an active control, and a HC group. Randomization was independently conducted by author C.G. He took no part in the implementation of assignments, the generation of the allocation sequence being his only role. On recruitment, patients were randomly assigned to either CRT or social skills training (SST) using computer-generated
Neuropsychological Outcomes
The result of the overall intent-to-treat analysis with the addition of baseline covariates was significant for time by condition (F2,47 = 3.918; p = .029; effect size .175) and also for different cognitive measures (Table 2). Additionally, univariate analyses showed a beneficial effect of CRT on different cognitive tests and cognitive domains (Figure 2), particularly for executive function (F2,47 = 8.469; p = .001; effect size .314), Verbal Memory (F2,47 = 6.029; p = .005; effect size .236)
Discussion
Patients exposed to the treatment showed a reduction in overactivation of the CEN during task-related responses and also in the deactivation of its anticorrelated DMN suggesting an improvement in the efficiency of both networks. On the other hand, an increase in white matter integrity in the genu of the corpus callosum was found in the CRT group after treatment. Functional and structural changes were correlated in the CRT group participants.
Previous studies have already shown a reduction in
References (62)
What are we changing with neurocognitive rehabilitation? Illustrations from two single cases of changes in neuropsychological performance and brain systems as measured by SPECT
Schizophr Res
(1998)- et al.
Brain perfusion and neuropsychological changes in schizophrenic patients after cognitive rehabilitation
Psychiatry Res
(2000) - et al.
How can cognitive remediation therapy modulate brain activations in schizophrenia? An fMRI study
Psychiatry Res
(2011) - et al.
Default-mode brain dysfunction in mental disorders: A systematic review
Neurosci Biobehav Rev
(2009) - et al.
Cognitive remediation therapy for outpatients with chronic schizophrenia: A controlled and randomized study
Schizophr Res
(2006) - et al.
Improved optimisation for the robust and accurate linear registration and motion correction of brain images
Neuroimage
(2002) - et al.
A global optimisation method for robust affine registration of brain images
Med Image Anal
(2001) - et al.
Tensorial extensions of independent component analysis for multisubject FMRI analysis
Neuroimage
(2005) - et al.
Voxel-based morphometry—the methods
Neuroimage
(2000) - et al.
A voxel-based morphometric study of ageing in 465 normal adult human brains
Neuroimage
(2001)