Priority CommunicationRapid Effects of Deep Brain Stimulation for Treatment-Resistant Major Depression
Section snippets
Methods and Materials
The Institutional Review Board of the University of Bonn approved of this study; the protocol is registered at ClinicalTrials.gov with the identifier NCT01095263. All patients gave written informed consent, and their individual inclusion criteria were reviewed by a psychiatrist not related to our group.
Demographic and Clinical Characteristics
All seven patients were diagnosed as severely treatment-resistant, with a mean length of current major depressive episode of 7.6 years (SD 5), and had 14 medical treatment courses on average (SD 3.5) with an antidepressant treatment resistance score (Modified Antidepressant Treatment History Form score) above 3 defining an adequate treatment dose and length, including augmentation and combination therapy. At the time of implantation, the mean number of antidepressant medications was 4 (SD 3.9).
Discussion
In this article, we report on effects of DBS to the slMFB in an unblinded trial in seven patients with extreme forms of treatment-resistant major depression. This approach and the results obtained are noteworthy for several reasons; the target selection was hypothesis-based, individual deterministic diffusion tensor imaging was used to identify target sites in each patient, the onset of antidepressant response was unexpectedly rapid, and last, the short-term antidepressant effects were more
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Authors TES and VAC contributed equally to this work.