Archival ReportWhite Matter Alterations at 33-Year Follow-Up in Adults with Childhood Attention-Deficit/Hyperactivity Disorder
Section snippets
Participants
The study was approved by the institutional review boards of New York University Langone Medical Center and New York University. Participants provided written informed consent and were compensated for participating.
Probands originally consisted of 207 6- to 12-year-old middle class Caucasian boys referred to a research clinic from 1970 to 1978 (mean±SD: 8.3±1.6 years) 22, 23, 24. Inclusion criteria were: school referral because of behavior problems, elevated parent and teacher hyperactivity
Subjects
A total of 152 participants were scanned at FU41, of whom 144 (61 probands, and 83 control subjects) underwent diffusion-weighted scans. The DTI data for 10 probands and 17 control subjects failed quality criteria, leaving 51 probands and 66 control subjects with analyzable DTI data. Rates of magnetic resonance imaging (MRI) refusal and failure to schedule or locate subjects did not differ significantly between probands and control subjects (45% vs. 43%). However, a smaller proportion of
Discussion
This is the first DTI study in adults with ADHD established in childhood. As expected, we found significantly decreased FA in probands relative to control subjects, regardless of ADHD diagnosis at mean age 41 years, in WM tracts connecting gray matter regions that we found to be abnormal in the same cohorts (21). Fractional anisotropy in probands with childhood ADHD was decreased relative to control subjects without childhood ADHD in a left hemisphere cluster encompassing the sagittal stratum
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2023, Biological Psychiatry: Cognitive Neuroscience and NeuroimagingAtypical development in white matter microstructures in ADHD: A longitudinal diffusion imaging study
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2022, Psychiatry Research - NeuroimagingCitation Excerpt :In addition to the forceps major, we found reduced FA in the left genu Internal capsule. These observed differences in the left genu internal capsule are consistent with the findings of previous ADHD studies in childhood (Dougherty Chase et al., 2016; Cortese Samuele et al., 2013). The internal capsule includes connections to cortical areas and subcortical areas, the latter include the brain stem, thalamus, and basal ganglia.