Archival ReportBody Mass Index–Related Regional Gray and White Matter Volume Reductions in First-Episode Mania Patients
Section snippets
Participants and Assessments
Patients and healthy subjects were enrolled in the University of British Columbia (UBC) Systematic Treatment Optimization Program for Early Mania (STOP-EM), a comprehensive study of clinical outcomes, cognition, brain morphology, and neurochemistry in recently remitted first-episode mania patients with BD. The UBC Clinical Research Ethics Board approved STOP-EM and the procedures outlined here. Written informed consent was obtained from participants before any study activities took place.
Participants
Fifty-seven of the 71 patients enrolled in STOP-EM, and all 30 of the healthy subjects, had baseline data for BMI and brain volumes and were included here. Twenty-five of the 33 healthy subjects enrolled in the first-episode psychosis study were also included; three were excluded for being outside the age range for STOP-EM and five for histories of serious head injuries. Thus, our sample comprised 57 patients and 55 healthy subjects. Their sociodemographic and clinical characteristics are
Discussion
This is the first hypothesis-driven test of, and supporting evidence for, our theory that elevated BMI is associated with unique brain changes in BD that have a negative impact on regions believed to be vulnerable in the illness. At recovery from their first manic episode, patients with elevated BMI had GM and WM reductions in frontal, temporal, and subcortical limbic areas implicated in the pathophysiology of BD. In contrast, age- and gender-matched healthy subjects had weight-related volume
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2021, Journal of Affective DisordersCitation Excerpt :Finally, while participants used by Nakamura et al. (2007) greatly overlapped with the three other studies, they examined neocortical gray matter regions separated by lobes, whereas the other studies examined more targeted structures. Ten of the 15 studies reported using 1.5T MRI scanners (Arango et al., 2012; de Castro-Manglano et al., 2011; Farrow et al., 2005; Kasai et al., 2003a, 2003b; Koo et al., 2008; Lee et al., 2016; Nakamura et al., 2007; Ohtani et al., 2018; Salisbury et al., 2007), three studies using 3.0T (Berk et al., 2017; Bond et al., 2014; Kozicky et al., 2016), one using 3.0T and 4.0T scanners (Bitter et al., 2011) (see Table 1). Data was not available for one study (Castro-Fornieles et al., 2018).
Higher body mass index associated with smaller frontal cortical volumes in older adult patients with bipolar disorder
2021, European Journal of Psychiatry