Archival ReportIn Vivo Hippocampal Subfield Volumes in Schizophrenia and Bipolar Disorder
Section snippets
Subjects
The subject sample (N = 702) consisted of patients with a DSM-IV diagnosis within the schizophrenia spectrum (n = 210; schizophrenia [DSM-IV 295.1, 295.3, 295.6, 295.9; n = 161], schizophreniform disorder [DSM-IV 295.4; n = 21], or schizoaffective disorder [DSM-IV 295.7; n = 28]), patients with a DSM-IV diagnosis within the bipolar spectrum (n = 192; bipolar I disorder [DSM-IV 296.0-7; n = 117], bipolar II disorder [DSM-IV 296.89; n = 66], or bipolar disorder not otherwise specified [DSM-IV
Demographic and Clinical Variables
Demographic and clinical variables are presented in Table 1.
Hippocampal Subfield Volume Differences Between Diagnostic Groups
Volume differences between groups (Table 2) were found in hippocampal subfields CA2/3, CA4/DG, presubiculum, and subiculum bilaterally and right CA1 when age and ICV were accounted for; patients with schizophrenia or bipolar disorder had smaller volumes than healthy control subjects for all subfields except the presubiculum, where only patients with schizophrenia had smaller volumes (Table 3). Both patient groups showed smaller right
Discussion
The main findings in this study were smaller in vivo volumes of the hippocampal subfields CA2/3, CA4/DG, subiculum, and right CA1 in patients with schizophrenia and patients with bipolar disorder compared with healthy control subjects, with distinctly smaller subiculum and presubiculum volumes in patients with schizophrenia compared with patients with bipolar disorder.
Subiculum and presubiculum constitute the outflow parts of the hippocampal neuronal circuitry (8) and receive the major output
Acknowledgment and disclosures
This work was supported by the Research Council of Norway Grant Nos. 190311/V50, 167153/V50, and 204966/F20; the South Eastern Norway Regional Health Authority Grant Nos. 2008011, 2009037, and 2011096; and the K.G. Jebsen Foundation. The funding organizations had no further role in study design; in the collection, analysis, or interpretation of data; in the writing of the article; or in the decision to submit the article for publication.
AMD is a founder and holds equity in CorTechs Labs and
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