Archival ReportError Processing and Inhibitory Control in Obsessive-Compulsive Disorder: A Meta-analysis Using Statistical Parametric Maps
Section snippets
Search and Inclusion of Studies
The meta-analysis was conducted in line with Meta-analysis of Observational Studies in Epidemiology group guidelines (43). The study protocol was registered with PROSPERO (No. CRD42017062495) and is accessible from http://www.crd.york.ac.uk/PROSPERO/display_record.php?ID=CRD42017062495.
A comprehensive literature search was performed using the PubMed, ScienceDirect, Web of Knowledge, and Scopus research databases through August 1, 2017. Reference lists of retrieved studies and recent
Included Studies and Characteristics
Nine datasets were available to be included as whole-brain t-maps in the current meta-analysis 4, 18, 23, 26, 35, 37, 41, 51, 52. One study was originally included as a conference abstract (51) but has been published subsequently as a full journal article (24). Peak coordinate data from a whole-brain analysis were available for a 10th dataset for the between-group error contrast (40). Yücel et al. provided a new unpublished dataset that partially overlapped with data included in their published
Discussion
Error processing and inhibitory control enable adaptive behavioral regulation and are hypothesized to be abnormal in OCD 3, 53. In this meta-analysis, patients with OCD showed impaired task performance relative to HCs during tasks of inhibitory control. In addition, patients showed hyperactivation relative to HCs during error processing in cingulo-opercular regions, including the dACC/SMA, pre-SMA, and right aI/fO, as well as in the right aLPFC. In contrast, patients primarily showed
Acknowledgments and Disclosures
This work was funded by National Institute of Mental Health Grant No. R01 MH102242 (to KF and SFT). LJN was supported as a postdoctoral fellow funded by Grant No. R01 MH102242 awarded to KF and SFT.
This work was presented as a poster presentation at the American College of Neuropsychopharmacology 56th annual meeting, Palm Springs, California, in 2017 as well as at the Society of Biological Psychiatry 73rd annual meeting, New York City, New York, in 2018.
SFT has received research support from
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