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Depressive symptoms during buprenorphine vs. methadone maintenance: findings from a randomised, controlled trial in opioid dependence

Published online by Cambridge University Press:  16 April 2020

Angela J. Dean ,
James Bell ,
Macdonald J. Christie  and
Richard P. Mattick
Angela J. Dean*
Affiliation:
Department of Psychiatry, University of Queensland4029, Australia The Langton Centre, Nobbs St, Surry Hills 2010, Australia Department of Pharmacology and Medical Foundation, University of Sydney2006, Australia
James Bell
Affiliation:
The Langton Centre, Nobbs St, Surry Hills 2010, Australia
Macdonald J. Christie
Affiliation:
Department of Pharmacology and Medical Foundation, University of Sydney2006, Australia
Richard P. Mattick
Affiliation:
National Drug and Alcohol Research Centre, University of New South Wales, 2052, Australia
*
*Corresponding author. Mater Centre for Service Research in Mental Health, Mater Misercordiae Health Services, Raymond Terrace, South Brisbane QLD 4001, Australia. Email address: a.dean@mailbox.uq.edu.au
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Abstract

Research suggests that buprenorphine may possess antidepressant activity. The Beck Depression Inventory was completed at baseline and 3 months by heroin dependent subjects receiving either buprenorphine or methadone maintenance as part of a larger, pre-existing, double blind trial conducted by NDARC (Australia). Depressive symptoms improved in all subjects, with no difference between methadone and buprenorphine groups, suggesting no differential benefit on depressive symptoms for buprenorphine compared to methadone.

Keywords

BuprenorphineAntidepressantDepressionOpioid dependenceMethadone
Type
Short communication
Information
European Psychiatry , Volume 19 , Issue 8 , December 2004 , pp. 510 - 513
Copyright
Copyright © European Psychiatric Association 2004

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