Shape changes of the corpus callosum in abstinent methamphetamine users
Section snippets
Acknowledgements
This work was supported in part by grants from the National Institute on Drug Abuse (DA09448-09S1) (I.K.L and P.F.R.), Stanley Medical Research Institute, NARSAD and the Harvard-MIT CITP, the Korean Research Foundation (I.K.L.) and National Institute on Drug Abuse (DA09448), the National Institute of Mental Health (MH58681) (P.F.R.).
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2013, Drug and Alcohol DependenceCitation Excerpt :Methamphetamine (METH) abuse is a disorder characterized by compulsive METH-craving and consumption despite an apparent awareness of serious negative consequences. METH use has been linked to the emergence of psychotic symptoms (Iyo et al., 2004; London et al., 2004; Winslow et al., 2007) as well as morphological, functional, and neurochemical abnormalities in multiple brain areas (Bae et al., 2006; Chung et al., 2007; Ernst et al., 2000; Hwang et al., 2006; Oh et al., 2005). Alterations in monoaminergic neurotransmission (Kokoshka et al., 1998; Ricaurte et al., 1980; Robinson and Berridge, 1993) in the frontal lobe have been related to cognitive impairments in METH users because prefrontal cortical neural networks play a central role in impaired decision-making and inhibitory control (Lubman et al., 2004; Yucel and Lubman, 2007).