Ketamine-related expression of glutamatergic postsynaptic density genes: Possible implications in psychosis
References (38)
- et al.
Method for quantitative in situ hybridization histochemistry and image analysis applied for Homer1a gene expression in rat brain
Brain Res. Brain Res. Protoc.
(2003) - et al.
Dopamine-glutamate reciprocal modulation of release and motor responses in the rat caudate-putamen and nucleus accumbens of “intact” animals
Brain Res. Brain Res. Rev.
(2005) - et al.
Acute administration of antipsychotics modulates Homer striatal gene expression differentially
Brain Res. Mol. Brain Res.
(2002) - et al.
N-methyl-d-aspartate antagonists are potent activators of ventral tegmental A10 dopamine neurons
Neurosci. Lett.
(1990) - et al.
Vesl, a gene encoding VASP/Ena family related protein, is upregulated during seizure, long-term potentiation and synaptogenesis
FEBS Lett.
(1997) - et al.
To model a psychiatric disorder in animals: schizophrenia as a reality test
Neuropsychopharmacology
(2000) - et al.
Loose ligation of the sciatic nerve in rats elicits transient up-regulation of Homer1a gene expression in the spinal dorsal horn
Neurosci. Lett.
(2006) - et al.
Expression of vesl-1S/homer-1a, a gene associated with long-term potentiation, in the brain of the epileptic EI mouse
Neurosci. Lett.
(2001) - et al.
N-methyl-d-aspartate receptor dependent transcriptional regulation of two calcium/calmodulin-dependent protein kinase type II isoforms in rodent cerebral cortex
Neuroscience
(2003) - et al.
Effect of dopamine denervation and dopamine agonist administration on serine phosphorylation of striatal NMDA receptor subunits
Brain Res.
(1999)
NMDA receptor hypofunction model of schizophrenia
J. Psychiatry Res.
Striatal cell signaling in chronically food-restricted rats under basal conditions and in response to brief handling
Neurosci. Lett.
Dopamine D(2) receptor occupancy is a common mechanism underlying animal models of antipsychotics and their clinical effects
Neuropsychopharmacology
Antipsychotic drugs classified by their effects on the release of dopamine and noradrenaline in the prefrontal cortex and striatum
Eur. J. Pharmacol.
Inhibition of methylphenidate-induced gene expression in the striatum by local blockade of D1 dopamine receptors: interhemispheric effects
Neuroscience
Identification of protein substrates of Ca(2+)/calmodulin-dependent protein kinase II in the postsynaptic density by protein sequencing and mass spectrometry
Biochem. Biophys. Res. Commun.
Corticolimbic dopamine neurotransmission is temporally dissociated from the cognitive and locomotor effects of phencyclidine
J. Neurosci.
Attenuation of the neuropsychiatric effects of ketamine with lamotrigine: support for hyperglutamatergic effects of N-methyl-d-aspartate receptor antagonists
Arch. Gen. Psychiatry
Homer: a protein that selectively binds metabotropic glutamate receptors
Nature
Cited by (42)
A molecular perspective on mGluR5 regulation in the antidepressant effect of ketamine
2024, Pharmacological ResearchUltrastructural evidence for glutamatergic dysregulation in schizophrenia
2022, Schizophrenia ResearchCitation Excerpt :This is consistent with our vGLUT2 findings and in the synaptic data in the dorsal striatum described above. In agreement with this finding is evidence for an increased expression of excitatory postsynaptic density proteins after ketamine stimulation and in the NAcc in postmortem schizophrenia (Kajimoto et al., 2003; Iasevoli et al., 2007). Rodent models of schizophrenia also exhibit increased indices of glutamatergic-type input in the NAcc.
Translating preclinical findings in clinically relevant new antipsychotic targets: focus on the glutamatergic postsynaptic density. Implications for treatment resistant schizophrenia
2019, Neuroscience and Biobehavioral ReviewsCitation Excerpt :The non-competitive NMDA-R antagonist PCP has been shown to restore normal levels of Homer1a in the PFC in D-aspartate-oxidase KO mice which have lower basal level of expression than wild-type (WT) mice (de Bartolomeis et al., 2015c), as well as it has been shown to modulate Homer1a mRNA within the prefrontal, primary auditory, and retrosplenial cortices in a time-dependent manner (Cochran et al., 2002). Similarly, ketamine enables Homer1a transcription in the rat ventral striatum (Iasevoli et al., 2007). Homer1a has been found to be instrumental for antidepressant mechanism in KO A1adenosine mouse model of depression (Serchov et al., 2015).
The Acute and Chronic Effects of Ketamine as Revealed by Noninvasive Brain Imaging
2016, Neuropathology of Drug Addictions and Substance Misuse