MicroRNAs miR-144/144* and miR-16 in peripheral blood are potential biomarkers for naturalistic stress in healthy Japanese medical students
Highlights
► Naturalistic stressor-responsive miRNAs in blood were analyzed by a miRNA array. ► Healthy medical students taking an academic examination were subjected to this study. ► Microarray analysis extracted 11 candidate miRNAs responsive to the stressor. ► Real-time RT-PCR identified miR-144/144* and miR-16 as stress-responsive miRNAs. ► Changes in miR-144* and miR-16 levels were associated with TNF-α and IFN-γ responses.
Section snippets
Conflicts of interest
The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.
Acknowledgements
This study was supported by the Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology, Japan (Nos. 22390146 and 22659142 to K.R.).
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