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Reduced baseline acetylated histone 3 levels, and a blunted response to HDAC inhibition in lymphocyte cultures from schizophrenia subjects

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    Furthermore, Brattleboro rat mimics core behavioral symptoms of schizophrenia, therefore it has substantial face validity (e.g. social withdrawal, pathological sensorimotor gating deficits (Braff and Geyer, 1990), memory dysfunction (Fodor et al., 2016b; Varga et al., 2014), social discrimination deficit (Demeter et al., 2016; Engelmann and Landgraf, 1994), social deficit (Schank, 2009; Schatz et al., 2018)). Regarding construct validity, upregulation of striatal dopamine D2 receptors, lower histone acetylation in prefrontal cortex and lateral septum and higher in hippocampus have been found in di/di rats, which resemble changes during schizophrenia (Demeter et al., 2016; Gavin et al., 2008; Shilling et al., 2006). Predictive validity requires antipsychotic effectiveness similar to that in humans.

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