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Estrogen Receptor Alpha Gene Polymorphisms and Breast Cancer Risk

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Abstract

We conducted a hospital-based case-control study to evaluate the association between the XbaI and PvuII restriction fragment length polymorphisms (RFLPs) in intron 1 of the estrogen receptor α (ERα) gene and breast cancer risk. The study population consisted of 205 histologically confirmed incident breast cancer cases and 205 age-matched controls with no present and previous history of cancer. The PvuII genotype distribution did not show any difference between cases and controls, but the adjusted odds ratio (OR) for the XbaI X allele containing genotypes was 0.4 (95% CI: 0.3–0.6) compared with the xx genotype. The decrease in the OR appeared to be more attributable to the postmenopausal women; the ORs were 0.3 (95% CI: 0.1–0.5) and 0.5 (95% CI: 0.3–0.9) for postmenopausal and premenopausal women, respectively. Our results therefore suggest that the ERα XbaI polymorphism modifies individual susceptibility to breast cancer in Korean women.

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Authors and Affiliations

  1. Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, South Korea

    Aesun Shin, Daehee Kang, Sook-Un Kim, Ju Han Kim & Keun-Young Yoo

  2. Division of Public Health, Kobe University Graduate School of Medicine, Kobe, Japan

    Hisahide Nishio & Myeong Jin Lee

  3. Department of Preventive Medicine, Konkuk University College of Medicine, Chungcheongbuk-do, South Korea

    Sue Kyung Park

  4. Department of Surgery, Seoul National University College of Medicine, Seoul, South Korea

    Dong-Young Noh & Kuk-Jin Choe

  5. Department of Surgery, Ulsan University College of Medicine, Seoul, South Korea

    Se-Hyun Ahn

  6. Department of Industrial Hygiene and Toxicology, Finnish Institute of Occupational Health, Helsinki, Finland

    Ari Hirvonen

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  1. Aesun Shin
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  2. Daehee Kang
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  3. Hisahide Nishio
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  5. Sue Kyung Park
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  7. Dong-Young Noh
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  8. Kuk-Jin Choe
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  9. Se-Hyun Ahn
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  10. Ari Hirvonen
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  11. Ju Han Kim
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  12. Keun-Young Yoo
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Shin, A., Kang, D., Nishio, H. et al. Estrogen Receptor Alpha Gene Polymorphisms and Breast Cancer Risk. Breast Cancer Res Treat 80, 127–131 (2003). https://doi.org/10.1023/A:1024439202528

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  • DOI: https://doi.org/10.1023/A:1024439202528

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