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Psychomotor development in children exposed in utero to benzodiazepines, antidepressants, neuroleptics, and anti-epileptics

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Abstract

We did a follow-up study based upon a regional prescription register in Denmark. We identified all 435 women who in the period 1991–1996 had redeemed a prescription for CNS drugs during pregnancy. Among the rest of the pregnant women we randomly selected 1304 women who also had given birth to a child in the same region and period. We looked up the local health nurses Boel test results which were available for about 80%. Any abnormal test result was seen much more frequently among exposed (16%) than for not exposed (4%). The study has several limitations but raises concern that should be addressed in other and better designed studies.

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Authors and Affiliations

  1. Department of Clinical Epidemiology, Aarhus University and Aalborg Hospitals, Stengade 10, Box 561, Aalborg, Denmark

    J.T. Mortensen, H. Larsen & J. Bendsen

  2. The Department of Epidemiology and Social Medicine, University of Aarhus, Vennelyst Boulevard 6, Aarhus C, Denmark

    J.T. Mortensen

  3. The Danish Epidemiology Science Centre, University of Aarhus, Vennelyst Boulevard 6, Aarhus C, Denmark

    J. Olsen, C. Obel & H.T. Sørensen

Authors
  1. J.T. Mortensen
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  2. J. Olsen
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  3. H. Larsen
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  4. J. Bendsen
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  5. C. Obel
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  6. H.T. Sørensen
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Mortensen, J., Olsen, J., Larsen, H. et al. Psychomotor development in children exposed in utero to benzodiazepines, antidepressants, neuroleptics, and anti-epileptics. Eur J Epidemiol 18, 769–771 (2003). https://doi.org/10.1023/A:1025306304635

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  • DOI: https://doi.org/10.1023/A:1025306304635

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