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References
Gur RE, Keshavan MS, Lawrie SM . Schizophr Bull 2007; 33: 921–931.
Meisenzahl EM, Schmitt GJ, Scheuerecker J, Moller HJ . Int Rev Psychiatry 2007; 19: 337–345.
Lyon GJ, Abi-Dargham A, Moore H, Lieberman JA, Javitch JA, Sulzer D . Schizophr Bull 2011; 37: 108–117.
Heinz A, Romero B, Gallinat J, Juckel G, Weinberger DR . Pharmacopsychiatry 2003; 36: S152–S157.
Howes OD, Egerton A, Allan V, McGuire P, Stokes P, Kapur S . Curr Pharm Des 2009; 15: 2550–2559.
Laruelle M, Abi-Dargham A, Gil R, Kegeles L, Innis R . Biol Psychiatry 1999; 46: 56–72.
Howes OD, Kapur S . Schizophr Bull 2009; 35: 549–562.
Yung AR, Yuen HP, McGorry PD, Phillips LJ, Kelly D, Dell'Olio M et al. Aust N Z J Psychiatry 2005; 39: 964–971.
Cannon TD, Cadenhead K, Cornblatt B, Woods SW, Addington J, Walker E et al. Arch Gen Psychiatry 2008; 65: 28–37.
Howes OD, Montgomery AJ, Asselin MC, Murray RM, Valli I, Tabraham P et al. Arch Gen Psychiatry 2009; 66: 13–20.
Howes OD, Montgomery AJ, Asselin MC, Murray RM, Grasby PM, McGuire PK . Br J Psychiatry Suppl 2007; 51: s13–s18.
McGlashan TH, Zipursky RB, Perkins D, Addington J, Miller T, Woods SW et al. Am J Psychiatry 2006; 163: 790–799.
McGorry PD, Yung AR, Phillips LJ, Yuen HP, Francey S, Cosgrave EM et al. Arch Gen Psychiatry 2002; 59: 921–928.
Acknowledgements
This work was funded by grant U.1200.04.007.00001.01 from the Medical Research Council (MRC). We are grateful to the volunteers, staff of OASIS and LEO teams (South London and Maudsley NHS Foundation Trust) and GE Imanet.
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Howes, O., Bose, S., Turkheimer, F. et al. Progressive increase in striatal dopamine synthesis capacity as patients develop psychosis: a PET study. Mol Psychiatry 16, 885–886 (2011). https://doi.org/10.1038/mp.2011.20
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DOI: https://doi.org/10.1038/mp.2011.20
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