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Class reunion: PTEN joins the nuclear crew

Oncogene volume 24, pages 7394–7400 (2005)Cite this article

Abstract

Several recent reports have brought conclusive evidence that the tumor suppressor PTEN, once considered a strictly cytoplasmic protein, shuttles to the nuclear compartment, where it joins a variety of components of the same pathway it regulates in the cytoplasm, among which PI3K, PDK1 and AKT. In this review, we focus on the growing supporting evidence for an important physiological role of this nuclear pathway and on the role that alteration of this novel regulatory circuit may play during cell transformation.

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Acknowledgements

This work was supported by the National Institute of Health grant CA097097 to ADC and by an appropriation from the Commonwealth of Pennsylvania.

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  1. Human Genetics Program, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, 19111, PA, USA

    Zenglin Lian & Antonio Di Cristofano

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Correspondence to Antonio Di Cristofano.

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Lian, Z., Di Cristofano, A. Class reunion: PTEN joins the nuclear crew. Oncogene 24, 7394–7400 (2005). https://doi.org/10.1038/sj.onc.1209089

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