Antidepressants during pregnancy and lactation: Defining exposure and treatment issues
References (162)
- et al.
Amniotic fluid and umbilical cord blood concentrations of antidepressants in three women
Soc Biol Psychiatr
(2000) Screening methods for postpartum depression
J Obstet Gynecol Neonat Nurs
(1995)- et al.
Thyroid and adrenal measures during late pregnancy and the puerperium in women who have been major depressed or who become dysphoric postpartum
J Affect Disord
(1993) - et al.
The use of rating scales in postpartum depression
Recognizing and Treating Postpartum Depression. Report #11
(1993)- et al.
The effect of anxiety and depression during pregnancy on obstetric complications
Br J Obstet Gynecol
(1993) - et al.
Mode of delivery and subsequent stress response
Lancet
(2000) - et al.
Prenatal depression effects on neonates
Infant Behav Dev
(1999) - et al.
Serum prolactin levels and maintenance of progeny by prenatally-stressed female offspring
Experientia
(1979) - et al.
Effects of gestational undernutrition, stress and diazepam treatment on spatial discrimination learning and retention in young rats
Indian J Exp Biol
(1993)
Prenatal stress effects on functional development of the offspring
Prog Brain Res
Prenatal stress induces high anxiety and postnatal handling induces low anxiety in adult offspring: Correlation with stress-induced corticosterone secretion
J Neurosci
Prenatal exposure to predictable and unpredictable novelty stress and oxytocin treatment affects offspring development and behavior in rats
International J Neurosci
Prenatal stress exposure alters postnatal behavioral expression under conditions of novelty challenge in rhesus monkey infants
Dev Psychobiol
Sex-specific effects of prenatal stress on hypothalamic-pituitary-adrenal responses to stress and brain glucocorticoid receptor density in adult rats
Brain Res
Early developmental and temporal characteristics of stress-induced secretion of pituitary-adrenal hormones in prenatally stress rat pups
Brain Res
The effects of prenatal stress on the development of hypothalamic paraventricular neurons in fetal rats
Neuroscience
Prenatal stress selectively alters the reactivity of the hypothalamic-pituitary-adrenal system in female rats
Brain Res
Maternal glucocorticoid secretion mediates long-term effects of prenatal stress
J Neurosci
Permanent dopaminergic alterations in the nucleus accumbens after prenatal stress
Pharmacol Biochem Behav
Motor lateralization, behavioral despair and dopaminergic brain asymmetry after prenatal stress
Pharmacol Biochem Behav
Prenatal stress impairs maternal behavior in a conflict situation and reduces hippocampal benzodiazepine receptors
Life Sci
Prenatal stress: Effect on development of rat brain adrenergic receptors
Pharmacol Biochem Behav
Prenatal stress in rats facilitates amphetamine-induced sensitization and induces long-lasting changes in dopamine receptors in the nucleus accumbens
Brain Res
Maternal stress induces synaptic loss and developmental disabilities of offspring
International J Dev Neurosci
Maternal stress increases fetal brain and neonatal cerebral cortex 5-hydroxytryptamine synthesis in rats: A possible mechanism by which stress influences brain development
Pharmacol Biochem Behav
Effects of maternal stress during different gestational periods on the serotonergic system in adult rat offspring
Pharmacol Biochem Behav
Prenatal stress increases the behavioral response to serotonin agonists and alters open field behavior in the rat
Pharmacol Biochem Behav
Psychopathology in the children (ages 6–18) of depressed and normal parents
J Am Acad Child Psychiatr
Depression and the parenting of young children: making the case for early preventive mental health services
Harvard Rev Psychiatr
The effects of early postnatal stimulation on Morris water-maze acquisition in adult mice: Genetic and maternal factors
Psychopharmacology
Maternal behavior, pup vocalizations, and pup temperature changes following handling in mice of 2 inbred strains
Dev Psychobiol
Maternal separation in neonatal rats elicits activation of the hypothalamic-pituitary-adrenocortical axis: A putative role for corticotropin-releasing factor
Psychoneuroendocrinology
The pituitary-adrenocortical system of neonatal rats is responsive to stress throughout development in a time-dependent and stressor-specific fashion
Endocrinology
Maternal corticotropin-releasing hormone levels in the early third trimester predict length of gestation in human pregnancy
Am J Obstet Gynecol
Cortisol concentrations in the breast milk of women with major depression
Am Psychiatr Assoc
Psychotropic medications in lactation
J Clin Psychiatr
Mood disorders during pregnancy and lactation: Defining exposure and treatment issues
CNS Spectrums
Progression of depression in the prenatal and postpartum periods
Women Health
Causal attributions and perinatal depression
J Abnorm Psychol
Depressive attributional style and depression following childbrith
J Abnorm Psychol
Predicting depressive symptomatology: Cognitive-behavioural models and postpartum depression
J Abnorm Psychol
Psychiatric disorder in pregnancy and the first postnatal year
Br J Psychiatr
A prospective study of emotional disorders in childbearing women
Br J Psychiatr
Prospective study of postpartum depression: Prevalence, course, and predictive factors
Journal of Abnormal Psychology
A standardized interview that differentiates pregnancy and postpartum symptoms from perinatal clinical depression
Birth
Depression in women: Implications for health care research
Science
The prediction of major depression in women: Toward an integrated etiologic model
Am J Psychiatr
Postpartum depression: Identifying women at risk
Genesis
Postpartum depression: Identifying women at risk
Genesis
Cited by (46)
Pregnancy exposure to citalopram – Therapeutic drug monitoring in maternal blood, amniotic fluid and cord blood
2017, Progress in Neuro-Psychopharmacology and Biological PsychiatryCitation Excerpt :Additionally, long-term effects such as an increased risk of future psychopathology needs to be considered (Nulman et al., 2012) and the complexity of treating psychiatric disorders is further increased by the risk of maternal suicidal behavior (Paulzen et al., 2015a; Khalifeh et al., 2016). Although rarely investigated, some studies have demonstrated that all available antidepressants are able to cross the placenta to a varying degree (Newport et al., 2001; Hendrick et al., 2003; Ewing et al., 2015). Quantifying the extent of transplacental passage or knowledge about the accumulation of a drug in amniotic fluid as an important route of fetal exposure (Loughhead et al., 2006) can facilitate drug selection and ultimately provide insight into whether or not neonatal complications are directly related to drug exposure with measurable drug concentrations in amniotic fluid or fetal circulation.
Sertraline in pregnancy – Therapeutic drug monitoring in maternal blood, amniotic fluid and cord blood
2017, Journal of Affective DisordersCitation Excerpt :Through enzyme activity such as cytochromes (CYP) or UDP-glucuronosyltransferase (UGT), the human placenta is able to metabolize a large diversity of pharmacologically active molecules eliciting or inhibiting fetotoxic effects (Giaginis et al., 2012; Reimers et al., 2011). All available antidepressant drugs are able to cross the placenta to a varying degree (Hendrick et al., 2003; Newport et al., 2001). Quantifying the extent of transplacental passage or knowledge about the accumulation of a drug in amniotic fluid as an important route of fetal exposure (Loughhead et al., 2006) can facilitate drug selection and ultimately provide insight into whether or not neonatal complications are directly related to drug exposure with measurable drug concentrations in amniotic fluid or fetal circulation.
Evaluation of postpartum behaviour in rats treated with Hypericum perforatum during gestation
2013, Revista Brasileira de FarmacognosiaUse of long-acting injectable risperidone before and throughout pregnancy in schizophrenia
2007, Progress in Neuro-Psychopharmacology and Biological PsychiatryAnxiolytic agents and antidepressants
2005, Annales Medico-PsychologiquesPerinatal depression: Treatment options and dilemmas
2008, Journal of Psychiatry and NeuroscienceCitation Excerpt :The presence of antidepressants in an infant’s serum is not necessarily harmful in the short or long term. Conversely, an undetectable infant serum level does not mean that the infant is free from antidepressant exposure.237 Breast-milk analyses and measurements of infant antidepressant serum levels are not routinely obtained in clinical care.