Red Ginseng Inhibits Exercise-Induced Increase in 5-Hydroxytryptamine Synthesis and Tryptophan Hydroxylase Expression in Dorsal Raphe of Rats

Yeong-Ki Min; Seok-Hee Chung; Jong-Soo Lee; Sung-Soo Kim; Hyun-Dae Shin; Baek-Vin Lim; Min-Chul Shin; Mi-Hyeon Jang; Ee-Hwa Kim; Chang-Ju Kim

doi:10.1254/jphs.93.218

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Red Ginseng Inhibits Exercise-Induced Increase in 5-Hydroxytryptamine Synthesis and Tryptophan Hydroxylase Expression in Dorsal Raphe of Rats

Yeong-Ki Min, Seok-Hee Chung, Jong-Soo Lee, Sung-Soo Kim, Hyun-Dae Shin, Baek-Vin Lim, Min-Chul Shin, Mi-Hyeon Jang, Ee-Hwa Kim, Chang-Ju Kim

Author information

Yeong-Ki Min
Department of Oriental Rehabilitation Medicine, College of Oriental Medicine, Kyung Hee University
Seok-Hee Chung
Department of Oriental Rehabilitation Medicine, College of Oriental Medicine, Kyung Hee University
Jong-Soo Lee
Department of Oriental Rehabilitation Medicine, College of Oriental Medicine, Kyung Hee University
Sung-Soo Kim
Department of Oriental Rehabilitation Medicine, College of Oriental Medicine, Kyung Hee University
Hyun-Dae Shin
Department of Oriental Rehabilitation Medicine, College of Oriental Medicine, Kyung Hee University
Baek-Vin Lim
Department of Physiology, College of Medicine, Kyung Hee University
Min-Chul Shin
Department of Physiology, College of Medicine, Kyung Hee University
Mi-Hyeon Jang
Department of Physiology, College of Medicine, Kyung Hee University
Ee-Hwa Kim
Department of Meridianology, College of Oriental Medicine, Semyung University
Chang-Ju Kim
Department of Physiology, College of Medicine, Kyung Hee University

Keywords: Red ginseng, treadmill exercise, serotonin

JOURNAL FREE ACCESS

2003 Volume 93 Issue 2 Pages 218-221

DOI https://doi.org/10.1254/jphs.93.218

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Abstract

Red ginseng has been used as an ergogenic aid for endurance exercise. In this study, the effect of aqueous extract of Red ginseng on the endurance in treadmill exercise and 5-hydroxytryptamine (serotonin) synthesis and tryptophan hydroxylase expression in the dorsal raphe of rats were studied. Rats receiving Red ginseng showed increased time to exhaustion for treadmill running, and Red ginseng treatment inhibited exercise-induced increases in 5-hydroxytryptamine synthesis and tryptophan hydroxylase expression in the dorsal raphe. These results suggest that the suppressive effect of Red ginseng on serotonin level during exercise is a possible ergogenic mechanism of Red ginseng.

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