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Nuclear receptor coregulators are new players in nervous system development and function

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Abstract

Steroid/thyroid hormones and their cognate nuclear receptors (NRs) play important roles in nervous system development and function. The spatial and temporal gene expression that is regulated by NRs in the nervous system requires transcriptional intermediary coregualtors, designated as coactivators and corepressors. These coregulators enhance or repress transcriptional activity of NRs and modulate their target gene transcription. Recent progress has largely advanced our understanding of the molecular mechanisms by which NR coregulators function in the nervous system. This article summarizes our current knowledge about the molecular mechanisms, expression patterns, and biological functions of NR coactivators, such as the p160 steroid receptor coactivator family, CBP, p300, BRG1, TRAP220, PGC-1α, ERAP140, NIX1, and E6-AP, as well as corepressors such as NCoR and SMRT. Accumulated findings suggest that the functional spectrum of NR coregulators is much broader than was initially speculated, and these coregulators likely contribute to many physiological aspects of nervous system development and function.

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Authors and Affiliations

  1. Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX

    Eijun Nishihara, Bert W. O’Malley & Jianming Xu

  2. Division of Neurobiology and Behavior, Department of Translational Medical Sciences Course of Medical and Dental Sciences, Nagasaki University Graduate School of Biomedical Sciences, 1-12-4 Sakamoto, 852-8523, Nagasaki, Japan

    Eijun Nishihara

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  1. Eijun Nishihara
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Nishihara, E., O’Malley, B.W. & Xu, J. Nuclear receptor coregulators are new players in nervous system development and function. Mol Neurobiol 30, 307–325 (2004). https://doi.org/10.1385/MN:30:3:307

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