Context-processing deficits in schizophrenia: converging evidence from three theoretically motivated cognitive tasks

J Abnorm Psychol. 1999 Feb;108(1):120-33. doi: 10.1037//0021-843x.108.1.120.

Abstract

To test the hypothesis that the ability to actively represent and maintain context information in a central function of working memory and that a disturbance in this function contributes to cognitive deficits in schizophrenia, the authors modified 3 tasks--the AX version of the Continuous Performance Test, Stroop, and a lexical disambiguation task--and administered them to patients with schizophrenia as well as to depressed and healthy controls. The results suggest an accentuation of deficits in patients with schizophrenia in context-sensitive conditions and cross-task correlations of performance in these conditions. However, the results do not definitively eliminate the possibility of a generalized deficit. The significance of these findings is discussed with regard to the specificity of deficits in schizophrenia and the hypothesis concerning the neural and cognitive mechanisms that underlie these deficits.

Publication types

  • Clinical Trial
  • Comparative Study
  • Controlled Clinical Trial
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Age of Onset
  • Analysis of Variance
  • Cognition Disorders / diagnosis
  • Cognition Disorders / etiology*
  • Depressive Disorder, Major / diagnosis
  • Depressive Disorder, Major / etiology*
  • Female
  • Humans
  • Male
  • Memory, Short-Term / physiology
  • Middle Aged
  • Psychiatric Status Rating Scales
  • Psychomotor Performance*
  • Schizophrenia / complications*
  • Sensitivity and Specificity