Phencyclidine-induced stereotyped behavior in monkeys: antagonism by pimozide

Eur J Pharmacol. 1978 Dec 1;52(3-4):379-84. doi: 10.1016/0014-2999(78)90293-5.

Abstract

The psychotomimetic substance, phencyclidine (PCP), was administered chronically to selected members of a primate social colony. PCP induced stereotyped behavior in all treated monkeys at each of three test doses. Furthermore, there was a significant increase in the amount of stereotypy seen during the second and third weeks of treatment compared to the first week. The dopamine receptor blocking agent pimozide antagonized PCP stereotypy. The results are discussed in terms of dopamine mediation of these responses.

MeSH terms

  • Animals
  • Behavior / drug effects*
  • Female
  • Haplorhini
  • Humans
  • Macaca
  • Male
  • Phencyclidine / antagonists & inhibitors*
  • Pimozide / pharmacology*
  • Stereotyped Behavior / drug effects*
  • Time Factors

Substances

  • Pimozide
  • Phencyclidine