Abstract
The purpose of this study was to further examine the effect of activation of 5-HT(1A) and 5-HT(1B) receptors in the forced swim test in mice and to determine if activation of these receptors played a role in the mediation of the effects of the tricyclic antidepressant imipramine. The 5-HT(1A) agonist 8-OH-DPAT decreased immobility in the forced swim test in mice as previously described. Both the selective 5-HT(1B) agonist anpirtoline (1.25-5 mg/kg) and mixed 5-HT(1A/B) agonist RU24969 (0.6-2.5 mg/kg) significantly increased time spent swimming in the FST.
MeSH terms
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8-Hydroxy-2-(di-n-propylamino)tetralin / pharmacology
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Animals
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Antidepressive Agents, Tricyclic / pharmacology
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Behavior, Animal / drug effects
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Behavior, Animal / physiology*
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Dose-Response Relationship, Drug
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Female
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Imipramine / pharmacology
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Indoles / pharmacology
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Mice
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Mice, Inbred Strains
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Motor Activity / drug effects
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Motor Activity / physiology*
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Oxadiazoles / pharmacology
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Piperazines / pharmacology
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Piperidines / pharmacology
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Pyridines / pharmacology
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Reaction Time / drug effects
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Receptor, Serotonin, 5-HT1B
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Receptors, Serotonin / physiology*
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Receptors, Serotonin, 5-HT1
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Serotonin Antagonists / pharmacology
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Serotonin Receptor Agonists / pharmacology
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Swimming / physiology
Substances
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Antidepressive Agents, Tricyclic
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Indoles
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Oxadiazoles
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Piperazines
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Piperidines
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Pyridines
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Receptor, Serotonin, 5-HT1B
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Receptors, Serotonin
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Receptors, Serotonin, 5-HT1
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Serotonin Antagonists
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Serotonin Receptor Agonists
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5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1H indole
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GR 127935
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anpirtoline
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N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide
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8-Hydroxy-2-(di-n-propylamino)tetralin
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Imipramine