[Effects of S-adenosylmethionine and S-adenosylhomocysteine on in vivo synthesis of noradrenaline and serotonin in different parts of the rat brain]

P Fonlupt; J Barailler; M Roche; L Cronenberger; H Pacheco

[Effects of S-adenosylmethionine and S-adenosylhomocysteine on in vivo synthesis of noradrenaline and serotonin in different parts of the rat brain]

C R Seances Acad Sci D. 1979 Jan 15;288(2):283-6.

[Article in French]

Authors

P Fonlupt, J Barailler, M Roche, L Cronenberger, H Pacheco

PMID: 111855

Abstract

S-adenosylmethionine (0,1 mg/kg/ip) decreases in vivo, norepinephrine (NE) synthesis and does not affect 5-hydroxytryptamine (5 HT) synthesis in the Rat brain. S-adenosylhomocysteine (7 mg/kg/ip) increases NE synthesis and decreases 5 HT synthesis. Neither nucleoside affects dopamine synthesis.

Publication types

English Abstract

MeSH terms

Animals
Brain / metabolism*
Homocysteine / analogs & derivatives*
Norepinephrine / metabolism*
Rats
S-Adenosylhomocysteine / pharmacology*
S-Adenosylmethionine / pharmacology*
Serotonin / metabolism*

Substances

Homocysteine
Serotonin
S-Adenosylmethionine
S-Adenosylhomocysteine
Norepinephrine