Abstract
The effect of treatment with the acute GABAA receptor agonist THIP and the GABAB receptor agonist baclofen on apomorphine-induced aggressive behavior was studied in adult male Wistar rats. Both THIP (10 mg/kg i.p.) and baclofen (8 mg/kg i.p.) attenuated the aggressiveness, thereby indicating the involvement of GABAergic neurotransmission in the mediation of apomorphine-induced aggressiveness. On the basis of our data it can be proposed that both GABAA and GABAB receptor subtypes are involved in the neurobiology of apomorphine-induced aggressive behavior, as this phenomenon is evidently subject to the general inhibitory effect of GABAergic neurotransmission.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Aggression / drug effects*
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Aggression / physiology
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Animals
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Apomorphine
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Baclofen / pharmacology*
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Behavior, Animal / drug effects*
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Behavior, Animal / physiology
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Disease Models, Animal
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GABA Agonists / pharmacology*
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Isoxazoles / pharmacology*
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Male
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Neurotransmitter Agents / biosynthesis
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Neurotransmitter Agents / physiology
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Psychotic Disorders / physiopathology
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Rats
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Rats, Wistar
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Receptors, GABA-A / drug effects
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Receptors, GABA-B / drug effects
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Synaptic Transmission / drug effects*
Substances
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GABA Agonists
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Isoxazoles
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Neurotransmitter Agents
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Receptors, GABA-A
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Receptors, GABA-B
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Baclofen
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gaboxadol
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Apomorphine