Sortilin/neurotensin receptor-3: a new tool to investigate neurotensin signaling and cellular trafficking?

Cell Signal. 2001 Jan;13(1):1-6. doi: 10.1016/s0898-6568(00)00130-3.

Abstract

The identification of gp95sortilin, a sorting protein, as being the 100 kDa neurotensin (NT) receptor, a non-G-protein coupled receptor, constitutes a new and interesting but intriguing step in the neuropeptide signaling as well as in cellular trafficking. The isolation of the same protein by three different experimental approaches sum up the complexity for researchers involved in the functional significance of the so-called sortilin/neurotensin receptor 3 (NTR3). This review will concentrate on the putative physiological and cellular roles of sortilin/NTR3 as most results so far have proposed hypothetical conclusions rather than concrete evidence.

Publication types

  • Review

MeSH terms

  • Adaptor Proteins, Vesicular Transport
  • Animals
  • Brain / physiology
  • Cloning, Organism / methods
  • Humans
  • Membrane Glycoproteins / metabolism*
  • Membrane Proteins*
  • Nerve Tissue Proteins / metabolism*
  • Neurotensin / metabolism*
  • Protein Processing, Post-Translational / physiology
  • Protein Transport / physiology*
  • Receptors, Immunologic / physiology
  • Receptors, Lipoprotein*
  • Receptors, Neurotensin / metabolism*
  • Receptors, Scavenger
  • Scavenger Receptors, Class B
  • Signal Transduction / physiology*

Substances

  • Adaptor Proteins, Vesicular Transport
  • Membrane Glycoproteins
  • Membrane Proteins
  • Nerve Tissue Proteins
  • Receptors, Immunologic
  • Receptors, Lipoprotein
  • Receptors, Neurotensin
  • Receptors, Scavenger
  • Scarb1 protein, mouse
  • Scavenger Receptors, Class B
  • Neurotensin
  • sortilin