Abstract
Recent studies indicate that a protracted daily administration of the antidepressant fluoxetine to adult rats increases cell proliferation/neurogenesis in the hippocampus. It has been hypothesized that this action of fluoxetine might be mediated by neurotrophic factors. We hypothesized that glial S100beta could be such a factor, and using quantitative Western immunoblotting, we investigated the effect of a 21-day treatment of rats with fluoxetine (5 mg/kg), and found that fluoxetine increases the content of hippocampal S100beta.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antidepressive Agents, Second-Generation / pharmacology*
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Calcium-Binding Proteins / drug effects*
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Calcium-Binding Proteins / metabolism
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Fluoxetine / pharmacology*
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Hippocampus / drug effects*
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Hippocampus / metabolism
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Injections, Intraperitoneal
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Nerve Growth Factors / drug effects*
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Nerve Growth Factors / metabolism
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Rats
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Rats, Inbred BN
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S100 Calcium Binding Protein beta Subunit
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S100 Proteins*
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Time Factors
Substances
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Antidepressive Agents, Second-Generation
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Calcium-Binding Proteins
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Nerve Growth Factors
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S100 Calcium Binding Protein beta Subunit
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S100 Proteins
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Fluoxetine