Sleep, feeding, and neuropeptides: roles of orexins and orexin receptors

Michihiro Mieda; Masashi Yanagisawa

doi:10.1016/s0959-4388(02)00331-8

Sleep, feeding, and neuropeptides: roles of orexins and orexin receptors

Curr Opin Neurobiol. 2002 Jun;12(3):339-45. doi: 10.1016/s0959-4388(02)00331-8.

Authors

Michihiro Mieda¹, Masashi Yanagisawa

Affiliation

¹ Howard Hughes Medical Institute, Department of Molecular Genetics, University of Texas, Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9050, USA.

PMID: 12049942
DOI: 10.1016/s0959-4388(02)00331-8

Abstract

Recent studies using molecular genetics in mice and dogs, as well as histopathological analyses of human disease, have come to the same conclusion: the human sleep disorder narcolepsy is caused by failure of signaling mediated by orexin (hypocretin) neuropeptides. These and other findings strongly suggest that the orexin system plays a critical role in sleep/wake regulation. In addition, the orexin system may link energy homeostasis to the regulation of sleep/wake cycles.

Publication types

Review

MeSH terms

Animals
Carrier Proteins / genetics
Carrier Proteins / physiology*
Feeding Behavior / physiology*
Humans
Intracellular Signaling Peptides and Proteins*
Narcolepsy / genetics
Narcolepsy / metabolism
Neuropeptides / deficiency
Neuropeptides / genetics
Neuropeptides / physiology*
Orexin Receptors
Orexins
Receptors, G-Protein-Coupled
Receptors, Neuropeptide / genetics
Receptors, Neuropeptide / physiology*
Sleep / physiology*

Substances

Carrier Proteins
Intracellular Signaling Peptides and Proteins
Neuropeptides
Orexin Receptors
Orexins
Receptors, G-Protein-Coupled
Receptors, Neuropeptide