Abstract
The dopamine transporter (DAT) and the serotonin transporter (5-HTT) play important roles in methamphetamine (METH) dependence because they are the target of METH action. For this study, the association between the DAT and 5-HTT polymorphisms and METH dependence were investigated for a Chinese-male sample population. The investigated polymorphisms included those of the DAT 3'-variable number tandem repeat, the 5-HTT gene promoter and a 5-HTT variable number tandem repeat polymorphisms. No significant difference was demonstrated for genotype or allele frequency, when comparing METH dependent and control cases for the DAT and the 5-HTT polymorphisms. The findings of this study suggest that these polymorphisms do not play major roles in METH dependence in the Chinese-male population.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Asian People
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Carrier Proteins / genetics*
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Chi-Square Distribution
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Dopamine / metabolism*
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Dopamine Plasma Membrane Transport Proteins
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Gene Frequency / genetics
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Genotype
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Humans
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Male
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Membrane Glycoproteins / genetics*
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Membrane Transport Proteins / genetics*
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Methamphetamine*
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Minisatellite Repeats / genetics
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Nerve Tissue Proteins*
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Polymorphism, Genetic / genetics*
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Serotonin / metabolism*
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Serotonin Plasma Membrane Transport Proteins
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Substance-Related Disorders / genetics*
Substances
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Carrier Proteins
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Dopamine Plasma Membrane Transport Proteins
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Membrane Glycoproteins
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Membrane Transport Proteins
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Nerve Tissue Proteins
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SLC6A3 protein, human
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SLC6A4 protein, human
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Serotonin Plasma Membrane Transport Proteins
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Serotonin
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Methamphetamine
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Dopamine