Combination of amisulpride and olanzapine in treatment-resistant schizophrenic psychoses

Mathias Zink; Fritz A Henn; Johannes Thome

doi:10.1016/j.eurpsy.2003.09.002

Combination of amisulpride and olanzapine in treatment-resistant schizophrenic psychoses

Eur Psychiatry. 2004 Feb;19(1):56-8. doi: 10.1016/j.eurpsy.2003.09.002.

Authors

Mathias Zink¹, Fritz A Henn, Johannes Thome

Affiliation

¹ Clinic of Psychiatry and Psychotherapy, Central Institute of Mental Health, P.O. Box 12 21 20, 68072 Mannheim, Germany. zink@kv.zi-mannheim.de

PMID: 14969782
DOI: 10.1016/j.eurpsy.2003.09.002

Abstract

Treatment-resistant schizophrenia often leads to combined application of antipsychotic drugs. We report first experience with the combination of olanzapine and amisulpride. Improvement of psychopathological state and side effects could be achieved, and drug doses were lower than under monotherapy. We thus conclude that this approach represents a useful therapeutic option.

MeSH terms

Adult
Amisulpride
Antipsychotic Agents / therapeutic use*
Benzodiazepines / therapeutic use*
Drug Resistance*
Drug Therapy, Combination
Female
Humans
Male
Middle Aged
Olanzapine
Psychotic Disorders / drug therapy*
Psychotic Disorders / etiology*
Retrospective Studies
Schizophrenia / complications*
Sulpiride / analogs & derivatives*
Sulpiride / therapeutic use*

Substances

Antipsychotic Agents
Benzodiazepines
Sulpiride
Amisulpride
Olanzapine