Abstract
The ability of repeated D-amphetamine (2 mg/kg) treatment to induce behavioral sensitization in rats and alter glial fibrillary acidic protein (GFAP), dopamine transporter (DAT) and glutamate transporter-1 (GLT-1) immunoreactivities was assessed after a 10-day drug abstinence period. Results showed that a sensitizing regimen of amphetamine caused a persistent increase in the number of GFAP-positive cells in the dorsal and ventral caudate-putamen. DAT and GLT-1 immunoreactivities were unaffected. Although the elevated GFAP expression may be due to a mild neurotoxicity, it is also possible that amphetamine-induced increases in GFAP reflect adaptive changes that may be associated with processes underlying behavioral sensitization.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Transport System X-AG / metabolism
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Amphetamine / pharmacology*
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Animals
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Behavior, Animal / drug effects
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Caudate Nucleus / drug effects
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Caudate Nucleus / metabolism*
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Central Nervous System Stimulants / pharmacology*
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Conditioning, Operant / drug effects
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Dopamine Plasma Membrane Transport Proteins
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Glial Fibrillary Acidic Protein / biosynthesis*
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Immunohistochemistry
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Injections, Intraperitoneal
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Male
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Membrane Glycoproteins / metabolism
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Membrane Transport Proteins / metabolism
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Motor Activity / drug effects
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Nerve Tissue Proteins / metabolism
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Putamen / drug effects
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Putamen / metabolism*
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Rats
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Rats, Sprague-Dawley
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Stimulation, Chemical
Substances
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Amino Acid Transport System X-AG
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Central Nervous System Stimulants
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Dopamine Plasma Membrane Transport Proteins
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Glial Fibrillary Acidic Protein
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Membrane Glycoproteins
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Membrane Transport Proteins
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Nerve Tissue Proteins
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Slc6a3 protein, rat
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Amphetamine