Abstract
Maternal infection during pregnancy is associated with increased risk for neurodevelopmental disorders. Polyriboinosinic-polyribocytidilic acid (poly I:C) or saline was administered to rats to model maternal infection; levels of TNFalpha, brain-derived neurotrophic factor (BDNF), and nerve growth factor (NGF) were determined by ELISA. TNFalpha was significantly increased in maternal plasma, placenta, and amniotic fluid, while it was significantly decreased in fetal liver/spleen and neonatal brain. NGF and BDNF were significantly decreased in the placenta and fetal liver/spleen. There was no change in BDNF or NGF in the fetal or neonatal brain. Changes in TNFalpha, BDNF, and NGF after maternal exposure to poly I:C represent a potential mechanism through which maternal infection increases risk for neurodevelopmental disorders.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amniotic Fluid / immunology
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Amniotic Fluid / metabolism
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Animals
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Animals, Newborn
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Brain / drug effects
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Brain / metabolism
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Brain-Derived Neurotrophic Factor / antagonists & inhibitors
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Brain-Derived Neurotrophic Factor / biosynthesis*
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Brain-Derived Neurotrophic Factor / blood
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Down-Regulation / drug effects
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Down-Regulation / immunology
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Female
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Injections, Intraperitoneal
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Liver / drug effects
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Liver / embryology
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Liver / metabolism
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Maternal Exposure*
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Maternal-Fetal Exchange / drug effects*
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Maternal-Fetal Exchange / immunology
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Nerve Growth Factor / antagonists & inhibitors
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Nerve Growth Factor / biosynthesis*
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Nerve Growth Factor / blood
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Poly I-C / administration & dosage
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Poly I-C / pharmacology*
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Pregnancy
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Pregnancy Proteins / antagonists & inhibitors
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Pregnancy Proteins / biosynthesis
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Prenatal Exposure Delayed Effects*
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Rats
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Rats, Sprague-Dawley
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Spleen / drug effects
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Spleen / embryology
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Spleen / metabolism
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Tumor Necrosis Factor-alpha / antagonists & inhibitors
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Tumor Necrosis Factor-alpha / biosynthesis*
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Tumor Necrosis Factor-alpha / physiology
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Up-Regulation / drug effects
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Up-Regulation / immunology
Substances
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Brain-Derived Neurotrophic Factor
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Pregnancy Proteins
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Tumor Necrosis Factor-alpha
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Nerve Growth Factor
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Poly I-C