Abstract
The tryptophan hydroxylase-2 gene (TPH2) codes for the enzyme of serotonin (5-HT) synthesis in the brain and variation of TPH2 has been implicated in disorders of emotion regulation. Here, we used functional magnetic resonance imaging (fMRI) to demonstrate that a potentially functional variant of TPH2 modulates amygdala responsiveness to emotional stimuli of both negative and positive valence.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Adolescent
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Adult
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Amygdala / enzymology*
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DNA Mutational Analysis
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Emotions / physiology*
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Female
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Genetic Markers / genetics
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Genetic Predisposition to Disease / genetics
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Genetic Testing
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Genetic Variation / genetics*
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Genotype
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Humans
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Magnetic Resonance Imaging
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Male
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Mood Disorders / enzymology
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Mood Disorders / genetics
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Mood Disorders / physiopathology
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Mutation / genetics
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Neuropsychological Tests
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Photic Stimulation
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Serotonin / biosynthesis*
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Tryptophan Hydroxylase / genetics*
Substances
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Genetic Markers
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Serotonin
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TPH2 protein, human
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Tryptophan Hydroxylase