Role of glucocorticoids in dopamine-related neuropsychiatric disorders

Mol Cell Endocrinol. 2005 Dec 21;245(1-2):10-22. doi: 10.1016/j.mce.2005.10.007. Epub 2005 Nov 28.

Abstract

'Psychoneuroendocrinology' is now quickly emerging as a hot interdisciplinary research field that addresses the interplay between neuronal and endocrine signaling in psychiatric diseases. Both glucocorticoid hormones and dopamine have an important role in maintaining normal brain functions. In this review, molecular and mechanistic aspects of glucocorticoid effects on brain function and behavior will be discussed with specific reference to dopamine signaling.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Behavior, Addictive / physiopathology
  • Depressive Disorder, Major / physiopathology
  • Dopamine / genetics
  • Dopamine / physiology*
  • Epigenesis, Genetic
  • Gene Expression Regulation / physiology
  • Glucocorticoids / genetics
  • Glucocorticoids / physiology*
  • Humans
  • Mental Disorders / physiopathology*
  • Neurotransmitter Agents / physiology
  • Parkinson Disease / physiopathology
  • Receptor Cross-Talk / physiology
  • Receptors, Dopamine / genetics
  • Receptors, Dopamine / physiology
  • Receptors, Glucocorticoid / genetics
  • Receptors, Glucocorticoid / physiology
  • Schizophrenia / physiopathology
  • Signal Transduction

Substances

  • Glucocorticoids
  • Neurotransmitter Agents
  • Receptors, Dopamine
  • Receptors, Glucocorticoid
  • Dopamine