Abstract
NRG1, encoding neuregulin 1, is a susceptibility gene for schizophrenia, but no functional mutation causally related to the disorder has yet been identified. Here we investigate the effects of a variant in the human NRG1 promoter region in subjects at high risk of schizophrenia. We show that this variant is associated with (i) decreased activation of frontal and temporal lobe regions, (ii) increased development of psychotic symptoms and (iii) decreased premorbid IQ.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Brain Mapping*
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Cerebral Cortex / physiopathology*
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Cognition / physiology
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Cohort Studies
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Female
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Frontal Lobe / physiopathology
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Genetic Predisposition to Disease*
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Humans
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Intelligence / genetics
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Male
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Microsatellite Repeats / genetics
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Nerve Tissue Proteins / genetics*
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Nerve Tissue Proteins / metabolism
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Neuregulin-1
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Polymorphism, Single Nucleotide
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Psychotic Disorders / complications
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Psychotic Disorders / genetics*
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Risk Factors
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Schizophrenia / complications
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Schizophrenia / genetics*
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Temporal Lobe / physiopathology
Substances
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NRG1 protein, human
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Nerve Tissue Proteins
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Neuregulin-1