Association between a polymorphism in the promoter region of the TPH2 gene and the personality trait of harm avoidance

Martin Reuter; Yvonne Kuepper; Juergen Hennig

doi:10.1017/S1461145706007073

Association between a polymorphism in the promoter region of the TPH2 gene and the personality trait of harm avoidance

Int J Neuropsychopharmacol. 2007 Jun;10(3):401-4. doi: 10.1017/S1461145706007073. Epub 2006 Dec 19.

Authors

Martin Reuter¹, Yvonne Kuepper, Juergen Hennig

Affiliation

¹ Center of Psychobiology and Behavioral Medicine, Department of Psychology, Justus-Liebig University of Giessen, Otto-Behaghel-Strasse 10F, D-35394 Giessen, Germany. martin.reuter@psychol.uni-giessen.de

PMID: 17176491
DOI: 10.1017/S1461145706007073

Abstract

In a genetic association study the role of the -703 G/T (rs4570625) polymorphism, located in the promoter region of the tryptophan hydroxylase 2 gene (TPH2), in personality traits was investigated in a sample of 404 healthy Caucasian subjects. A significant association between harm avoidance (HA), a trait related to anxiety, and the -703 G/T polymorphism was detected supporting the findings by Gutknecht and colleagues.

MeSH terms

Adult
Aging / psychology
Alleles
Anxiety / psychology
DNA / genetics
Emotions / physiology
Exploratory Behavior / physiology
Female
Humans
Male
Personality / genetics*
Personality / physiology*
Personality Tests
Polymorphism, Genetic / genetics
Promoter Regions, Genetic / genetics
Reverse Transcriptase Polymerase Chain Reaction
Reward
Sex Characteristics
Temperament
Tryptophan Hydroxylase / genetics*

Substances

DNA
TPH2 protein, human
Tryptophan Hydroxylase