Abstract
We examined the relationship between COMT Val158Met genotype and temporal lobe volumes, including the caudate as a control region. Thirty-one healthy subjects completed 1.5T brain MRI and genotyping. After controlling for demographics, Val158 allele homozygotes exhibited significantly smaller temporal lobe and hippocampal volumes, with a trend for smaller amygdala volumes.
Publication types
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Comparative Study
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Research Support, N.I.H., Extramural
MeSH terms
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Adult
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Amygdala / anatomy & histology
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Amygdala / metabolism
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Brain / anatomy & histology
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Brain / enzymology
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Brain / metabolism
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Catechol O-Methyltransferase / genetics*
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Catechol O-Methyltransferase / metabolism
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Caudate Nucleus / anatomy & histology
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Caudate Nucleus / enzymology
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Caudate Nucleus / metabolism
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Female
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Functional Laterality / genetics
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Genotype
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Homozygote
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Humans
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Magnetic Resonance Imaging / statistics & numerical data*
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Male
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Methionine / genetics
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Methionine / metabolism
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Middle Aged
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Polymorphism, Single Nucleotide / genetics*
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Temporal Lobe / anatomy & histology*
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Temporal Lobe / enzymology
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Temporal Lobe / metabolism
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Valine / genetics
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Valine / metabolism
Substances
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Methionine
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Catechol O-Methyltransferase
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Valine