Abstract
Histone deactylase enzymes are responsible for the deacetylation of histone tails, and consequently influence gene regulation through their ability to modify chromatin structure surrounding promoter regions. We analyzed the microarray collection of the National Brain Databank to investigate differential expression of these enzymes in the prefrontal cortices of control, schizophrenia and bipolar subjects. HDAC1 expression levels were significantly higher in schizophrenia versus normal subjects. The mRNA expression level of an epigenetically regulated schizophrenia candidate gene GAD67 was strongly and negatively correlated with the mRNA expression levels of HDAC1, HDAC3 and HDAC4 levels. These findings provide additional support for the proposal that epigenetic factors are operative in the brain pathology of patients with schizophrenia.
Publication types
-
Comparative Study
-
Research Support, N.I.H., Extramural
MeSH terms
-
Adult
-
Age Factors
-
Aged
-
Aged, 80 and over
-
Bipolar Disorder / enzymology
-
Bipolar Disorder / genetics
-
Bipolar Disorder / metabolism
-
Databases, Genetic / statistics & numerical data
-
Epigenesis, Genetic / genetics
-
Female
-
Gene Expression Profiling / statistics & numerical data
-
Gene Expression*
-
Glutamate Decarboxylase
-
Histone Deacetylase 1
-
Histone Deacetylases / genetics*
-
Histone Deacetylases / metabolism
-
Humans
-
Male
-
Middle Aged
-
Prefrontal Cortex / enzymology
-
Prefrontal Cortex / metabolism*
-
Protein Array Analysis / statistics & numerical data
-
RNA, Messenger
-
Repressor Proteins / genetics
-
Repressor Proteins / metabolism
-
Schizophrenia / enzymology
-
Schizophrenia / genetics*
-
Schizophrenia / metabolism
-
Sex Factors
Substances
-
RNA, Messenger
-
Repressor Proteins
-
HDAC1 protein, human
-
HDAC4 protein, human
-
Histone Deacetylase 1
-
Histone Deacetylases
-
histone deacetylase 3
-
Glutamate Decarboxylase
-
glutamate decarboxylase 1