Abstract
In this review, we will provide a brief reminder of epigenetic phenomena in general, and DNA methylation in particular. We will then underline the characteristics of the in vivo organization of the genome that limit the applicability of in vitro results. We will use several examples to point out the connections between DNA methylation and nuclear architecture. Finally, we will outline some of the hopes and challenges for future research in the field. The study of DNA methylation, its effectors, and its roles, illustrates the complementarity of in vitro approaches and cell biology.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Cytosine / metabolism
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DNA (Cytosine-5-)-Methyltransferase 1
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DNA (Cytosine-5-)-Methyltransferases / genetics
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DNA (Cytosine-5-)-Methyltransferases / metabolism
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DNA / chemistry
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DNA / genetics
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DNA / metabolism
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DNA Methylation*
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DNA Replication
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Epigenesis, Genetic
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Gene Expression Regulation
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Mammals / genetics*
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Methyl-CpG-Binding Protein 2 / genetics
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Methyl-CpG-Binding Protein 2 / metabolism
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Models, Molecular
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Nuclear Proteins / metabolism
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Nucleic Acid Conformation
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Transcription Factors / genetics
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Transcription Factors / metabolism
Substances
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Methyl-CpG-Binding Protein 2
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Nuclear Proteins
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Transcription Factors
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Zbtb33 protein, mouse
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Cytosine
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DNA
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DNA (Cytosine-5-)-Methyltransferase 1
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DNA (Cytosine-5-)-Methyltransferases