Abstract
The relationship of plasma free homovanillic acid (HVA) and methoxyhydroxyphenylglycol (MHPG) to early clinical response was prospectively studied in a new series of acutely psychotic inpatients given a fixed dose of perphenazine elixir for 10 days. Elevated pretreatment plasma HVA but not MHPG was significantly associated with good response. Change in HVA was correlated with a favorable response and a significant decline in MHPG was found in responders. Results suggest that HVA can provide a useful clinical predictor of response, and that both dopamine metabolism and noradrenergic functioning, as measured by plasma HVA and MHPG, are reduced in effective neuroleptic treatment.
MeSH terms
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Acute Disease
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Adolescent
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Adult
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Bipolar Disorder / blood
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Bipolar Disorder / drug therapy
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Bipolar Disorder / psychology
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Chromatography, High Pressure Liquid
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Depressive Disorder / blood
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Depressive Disorder / drug therapy
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Depressive Disorder / psychology
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Dose-Response Relationship, Drug
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Drug Administration Schedule
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Female
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Follow-Up Studies
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Homovanillic Acid / blood*
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Humans
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Male
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Methoxyhydroxyphenylglycol / blood*
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Middle Aged
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Perphenazine / administration & dosage*
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Prognosis
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Prospective Studies
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Psychiatric Status Rating Scales*
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Psychotic Disorders / blood*
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Psychotic Disorders / drug therapy*
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Psychotic Disorders / psychology
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Schizophrenia / blood
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Schizophrenia / drug therapy
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Schizophrenic Psychology
Substances
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Methoxyhydroxyphenylglycol
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Perphenazine
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Homovanillic Acid