Abstract
In this review, we debate the evidence for abnormal white matter microstructure and myelination in bipolar disorder, as mainly detected by diffusion tensor imaging (DTI) studies. The effects of mood stabilizers on white matter are discussed, based on available findings from human and animal studies. Last, perspectives in this field of research are also drawn.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Bipolar Disorder / drug therapy
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Bipolar Disorder / pathology*
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Brain / drug effects
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Brain / pathology*
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Diffusion Magnetic Resonance Imaging
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Humans
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Lithium Compounds / pharmacology*
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Myelin Sheath / drug effects*
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Myelin Sheath / physiology*
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Neural Pathways / drug effects
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Neural Pathways / pathology
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Valproic Acid / pharmacology*
Substances
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Lithium Compounds
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Valproic Acid