Magnetic resonance tractography based on diffusion-tensor imaging was first introduced to the medical imaging community a decade ago. It has been successfully applied to a number of neurological conditions and most commonly used for preoperative planning for brain tumors and vascular malformations. Areas of active research include stroke, and dementia, where it provides valuable information not available through other imaging techniques. This technique was first introduced using the deterministic streamline algorithm and has evolved to use more sophisticated probabilistic approaches. We will review the past, present, and future of tractography, focusing primarily on its clinical applications.