Abstract
Orthodromic responses after local field stimulation were studied in a neostriatal slice preparation. Single suprathreshold stimuli evoked slow plateau-like orthodromic responses with repetitive firing and duration proportional to the stimulus intensity. Its persistence and apparent threshold upon hyperpolarization, as well as the actions of tetraethylammonium, QX-314 and Sr2+, suggest that this orthodromic response and associated phenomena such as fast prepotentials or Ca-dependent action potentials, may be generated on dendrites.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Action Potentials / drug effects
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Anesthetics, Local / pharmacology
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Animals
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Corpus Striatum / physiology*
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Dendrites / drug effects
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Dendrites / physiology*
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Electric Stimulation
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Evoked Potentials / drug effects
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In Vitro Techniques
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Lidocaine / analogs & derivatives
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Lidocaine / pharmacology
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Neurons / drug effects
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Neurons / physiology*
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Rats
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Rats, Inbred Strains
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Strontium / pharmacology
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Tetraethylammonium
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Tetraethylammonium Compounds / pharmacology
Substances
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Anesthetics, Local
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Tetraethylammonium Compounds
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QX-314
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Tetraethylammonium
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Lidocaine
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Strontium