White matter connectivity in bipolar disorder

Int Rev Psychiatry. 2009;21(4):380-6. doi: 10.1080/09540260902962172.

Abstract

There is evidence that intra- and inter-hemispheric white matter communication, mainly fronto-limbic and callosal connectivity, is impaired in bipolar disorder as reported in several magnetic resonance (MR) diffusion imaging studies. In this review we will discuss diffusion imaging studies that examined white matter integrity in patients with bipolar disorder, trying to outline future research strategies.

Publication types

  • Review

MeSH terms

  • Adolescent
  • Adult
  • Bipolar Disorder / pathology
  • Bipolar Disorder / physiopathology*
  • Brain / pathology
  • Brain / physiopathology*
  • Brain Mapping
  • Child
  • Corpus Callosum / pathology
  • Corpus Callosum / physiopathology
  • Diffusion Magnetic Resonance Imaging*
  • Dominance, Cerebral / physiology
  • Frontal Lobe / pathology
  • Frontal Lobe / physiopathology
  • Gyrus Cinguli / pathology
  • Gyrus Cinguli / physiopathology
  • Humans
  • Image Processing, Computer-Assisted*
  • Limbic System / pathology
  • Limbic System / physiopathology
  • Nerve Fibers, Myelinated / pathology
  • Nerve Fibers, Myelinated / physiology*
  • Nerve Net / pathology
  • Nerve Net / physiopathology
  • Neural Pathways / pathology
  • Neural Pathways / physiopathology*
  • Temporal Lobe / pathology
  • Temporal Lobe / physiopathology
  • Young Adult