Temporo-parietal junction stimulation in the treatment of depersonalization disorder

Antonio Mantovani; Daphne Simeon; Nina Urban; Peter Bulow; Anouk Allart; Sarah Lisanby

doi:10.1016/j.psychres.2010.08.022

Temporo-parietal junction stimulation in the treatment of depersonalization disorder

Psychiatry Res. 2011 Mar 30;186(1):138-40. doi: 10.1016/j.psychres.2010.08.022. Epub 2010 Sep 15.

Authors

Antonio Mantovani¹, Daphne Simeon, Nina Urban, Peter Bulow, Anouk Allart, Sarah Lisanby

Affiliation

¹ Division of Brain Stimulation and Therapeutic Modulation, Department of Psychiatry, Columbia University/New York State Psychiatric Institute, New York 10032, USA. am2518@columbia.edu

PMID: 20837362
DOI: 10.1016/j.psychres.2010.08.022

Abstract

This is the first clinical trial of repetitive Transcranial Magnetic Stimulation (rTMS) in depersonalization disorder (DPD). After 3weeks of right temporo-parietal junction (TPJ) rTMS, 6/12 patients responded. Five responders received 3 more weeks of right TPJ rTMS showing 68% DPD symptoms improvement. Right TPJ rTMS was safe and effective.

Publication types

Clinical Trial
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Cross-Over Studies
Deep Brain Stimulation / methods*
Depersonalization / therapy*
Female
Follow-Up Studies
Functional Laterality / physiology
Humans
Male
Middle Aged
Parietal Lobe / physiology*
Psychiatric Status Rating Scales
Temporal Lobe / physiology*
Treatment Outcome