Abstract
Chronic treatment (4 days) of ovariectomized rats with estrogen produced a two-fold shift to the left (with no change in the maximal percent inhibition) in the concentration response curve for the inhibition of adenylyl cyclase activity by 5-HT, but did not alter curves for R-PIA (adenosine A1 agonist) or Gpp(NH)p (to activate Gi). Furthermore, estrogen treatment had no effect on the number or affinity of 5-HT1A binding sites labeled with [3H]8-OH-DPAT. These data, when considered with the results of previous studies, suggest that estrogen treatment may selectively enhance 5-HT1A-mediated responses in rat hippocampus.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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8-Hydroxy-2-(di-n-propylamino)tetralin
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Adenylyl Cyclases / metabolism
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Animals
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Cell Membrane / drug effects
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Cell Membrane / physiology
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Colforsin / pharmacology
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Drug Implants
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Estradiol / pharmacology*
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Female
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Guanylyl Imidodiphosphate / pharmacology
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Hippocampus / drug effects
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Hippocampus / physiology*
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Kinetics
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Ovariectomy*
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Phenylisopropyladenosine / pharmacology
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Rats
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Rats, Inbred Strains
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Receptors, Serotonin / drug effects
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Receptors, Serotonin / metabolism
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Receptors, Serotonin / physiology*
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Tetrahydronaphthalenes / metabolism
Substances
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Drug Implants
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Receptors, Serotonin
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Tetrahydronaphthalenes
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Colforsin
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Phenylisopropyladenosine
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Guanylyl Imidodiphosphate
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Estradiol
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8-Hydroxy-2-(di-n-propylamino)tetralin
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Adenylyl Cyclases