Abstract
Serotonin has been implicated in the etiology of seasonal affective disorder (SAD). The authors compared the effect of the serotonergic precursor L-tryptophan, placebo, and artificial evening light on 13 SAD sufferers. L-Tryptophan and light were associated with greater improvement than was placebo, but the antidepressant effects of L-tryptophan and light were not significantly different.
Publication types
-
Clinical Trial
-
Comparative Study
-
Controlled Clinical Trial
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Clinical Trials as Topic
-
Depressive Disorder / drug therapy*
-
Depressive Disorder / physiopathology
-
Depressive Disorder / therapy
-
Humans
-
Phototherapy
-
Placebos
-
Psychiatric Status Rating Scales
-
Seasons*
-
Serotonin / physiology
-
Tryptophan / therapeutic use*
Substances
-
Placebos
-
Serotonin
-
Tryptophan