Abstract
Three case vignettes are presented documenting the rise in serum clozapine that occurred at a time of acute infection in these patients. The literature on this phenomenon is scant. The physiological processes that occur in the acute phase of the inflammatory response are summarized and provide an explanation of how clozapine levels may rise in response to infection. The risk of clozapine toxicity occurring in association with infections is highlighted.
MeSH terms
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Adult
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Antipsychotic Agents / pharmacokinetics
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Antipsychotic Agents / therapeutic use
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Antipsychotic Agents / toxicity*
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C-Reactive Protein / metabolism
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Clozapine / pharmacokinetics
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Clozapine / therapeutic use
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Clozapine / toxicity*
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Drug Therapy, Combination
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Escherichia coli Infections / blood
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Escherichia coli Infections / complications*
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Female
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Humans
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Leukocyte Count
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Male
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Middle Aged
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Pneumonia, Bacterial / blood
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Pneumonia, Bacterial / complications*
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Psychoses, Substance-Induced / blood
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Psychoses, Substance-Induced / diagnosis
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Psychoses, Substance-Induced / etiology*
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Psychotic Disorders / blood
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Psychotic Disorders / drug therapy*
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Psychotic Disorders / psychology
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Schizophrenia / blood
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Schizophrenia / drug therapy*
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Schizophrenic Psychology*
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Urinary Tract Infections / blood
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Urinary Tract Infections / complications*
Substances
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Antipsychotic Agents
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C-Reactive Protein
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Clozapine